Naproxen sodium has a longer half-life compared to other NSAID options, but headache relief rates at 2 hours after initial treatment are lower than ibuprofen. [6] [7] Naproxen sodium dosing recommendations: 550 mg every 12 hours; can increase the dosage to 825mg PO if needed; do not exceed the max of 1375 mg daily.
Diclofenac initiation also increased the risk of upper gastrointestinal bleeding at 30 days, by approximately 4.5-fold compared with no initiation, 2.5-fold compared with initiation of ibuprofen or paracetamol, and to a similar extent as naproxen initiation. Conclusions Diclofenac poses a cardiovascular health risk compared with non-use At doses of 200 mg per day or less, it doesn't appear to pose any greater heart attack risk than other NSAIDs. 5. Go generic. Generic over-the-counter pain relievers are less expensive than their brand-name counterparts, and work just as well. 6. Help for NSAID-related stomach woes.That study found that topical diclofenac was more effective than oral diclofenac 1 h after dosing (though not at later assessments) and that this efficacy coincided with higher tissue concentrations in the group that received topical administration (46.1 ± 25.8 ng/ml vs. 11.4 ± 2.09 ng/ml, P < 0.02) at about 1–1.5 h, when no diclofenac was
6 weeks:-0.3 (-0.4, -0.1); >99%† •• This study focused on the benefit/risk profile of diclofenac –– Based on effect size analysis, the probability that diclofenac compared with other traditional NSAIDs and COX-2 inhibitors in was better than naproxen was 92% at 6 weeks and 95% at -1 -0.5 0 0.5 1 1.5 patients with OA and RA.Diclofenac suppresses acute and chronic inflammation, pain and hyperthermia in various animal models, and in these models the drug has generally proven more potent, weight for weight, than aspirin, ibuprofen, naproxen and phenylbutazone, less potent than piroxicam, and similar to indomethacin. . 312 304 207 21 220 157 244 393 18